Abstract: From September 26 to 28, 2025, the 33rd CCF Beautiful Lake Seminar was held at the CCF Business Headquarters & Academic Exchange Center in Suzhou. With the theme of “Intelligent Sensing, Interpretation, and Applications of Spatiotemporal Information” , the seminar invited more than 20 leading experts from academia and industry to engage in in-depth exchanges and discussions. The discussions focused on four major aspects: physical mechanisms and intelligent sensing, fusion representation and open-world cognition, edge intelligence and trustworthy reasoning, and system collaboration and macro-level paradigms. Based on the outcomes of the discussions, the participating experts further summarized and refined the key insights, identifying ten core scientific issues that urgently need to be addressed in the field of intelligent spatiotemporal information sensing and interpretation. The seminar called for strengthening the interdisciplinary integration of computer science, artificial intelligence, remote sensing science, and related application fields, promoting the transition of spatiotemporal information processing from data sensing to intelligent cognition, advancing key technological innovation, research achievement transformation, and real-world application, and providing important support for intelligent earth observation, spatial information services, and decision support for complex systems.